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1

Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine

Kaddurah-Daouk, R, Weinshilboum, R

Journal:

Clinical Pharmacology & Therapeutics

Year:

2015

Language:

english

File:

PDF, 4.91 MB

english, 2015

2

Pharmacometabolomics of Statin Response

Krauss, R M, Zhu, H, Kaddurah-Daouk, R

Journal:

Clinical Pharmacology & Therapeutics

Year:

2013

Language:

english

File:

PDF, 419 KB

english, 2013

3

Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology

Kaddurah-Daouk, R, Weinshilboum, R M

Journal:

Clinical Pharmacology & Therapeutics

Year:

2014

Language:

english

File:

PDF, 1.41 MB

english, 2014

4

Pharmacometabolomics informs pharmacogenomics

Neavin, Drew, Kaddurah-Daouk, Rima, Weinshilboum, Richard

Journal:

Year:

2016

Language:

english

File:

PDF, 728 KB

english, 2016

5

Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes

Rotroff, DM, Shahin, MH, Gurley, SB, Zhu, H, Motsinger-Reif, A, Meisner, M, Beitelshees, AL, Fiehn, O, Johnson, JA, Elbadawi-Sidhu, M, Frye, RF, Gong, Y, Weng, L, Cooper-DeHoff, RM, Kaddurah-Daouk, R

Journal:

CPT: Pharmacometrics & Systems Pharmacology

Year:

2015

Language:

english

File:

PDF, 444 KB

english, 2015

6

Creatine and Creatinine Metabolism

Wyss, Markus, Kaddurah-Daouk, Rima

Journal:

Physiological Reviews

Year:

2000

Language:

english

File:

PDF, 1.20 MB

english, 2000

7

Current Concepts in Pharmacometabolomics, Biomarker Discovery, and Precision Medicine

Beger, Richard D., Schmidt, Michael A, Kaddurah-Daouk, Rima

Journal:

Year:

2020

Language:

english

File:

PDF, 1.34 MB

english, 2020

8

Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study

Ashwin A. Patkar, Steve Rozen, Paolo Mannelli, Wayne Matson, Chi-Un Pae, K. Ranga Krishnan, Rima Kaddurah-Daouk

Journal:

Psychopharmacology

Year:

2009

Language:

english

File:

PDF, 274 KB

english, 2009

9

Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions

Teresa W.-M. Fan, Peixiong Yuan, Andrew N. Lane, Richard M. Higashi, Yun Wang, Anahita B. Hamidi, Rulun Zhou, Xavier Guitart, Guang Chen, Husseini K. Manji, Rima Kaddurah-Daouk

Journal:

Year:

2010

Language:

english

File:

PDF, 1.07 MB

english, 2010

10

Metabolomics: A Global Biochemical Approach to Drug Response and Disease

Kaddurah-Daouk, Rima, Kristal, Bruce S., Weinshilboum, Richard M.

Journal:

Annual Review of Pharmacology

Year:

2008

Language:

english

File:

PDF, 772 KB

english, 2008

11

Amyotrophic lateral sclerosis: Transgenic model and novel neuroprotective agent

R. Kaddurah-Daouk, R. Matthews, M. Flint Beal

Journal:

Neuroscience Research Communications

Year:

2000

Language:

english

File:

PDF, 1.96 MB

english, 2000

12

A preliminary metabolomic analysis of older adults with and without depression

Lisa A. Paige, Matthew W. Mitchell, K. Ranga R. Krishnan, Rima Kaddurah-Daouk, David C. Steffens

Journal:

International Journal of Geriatric Psychiatry

Year:

2007

Language:

english

File:

PDF, 121 KB

english, 2007

13

Opioid use affects antioxidant activity and purine metabolism: preliminary results

Paolo Mannelli, Ashwin Patkar, Steve Rozen, Wayne Matson, Ranga Krishnan, Rima Kaddurah-Daouk

Journal:

Human Psychopharmacology: Clinical and Experimental

Year:

2009

Language:

english

File:

PDF, 154 KB

english, 2009

14

Synthesis and creatine kinase inhibitory activity of non-hydrolyzable analogs of phosphocreatine

Gustave Bergnes, Rima Kaddurah-Daouk

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 302 KB

english, 1997

15

Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation

Ole A. Andreassen, Bruce G. Jenkins, Alpaslan Dedeoglu, Kimberly L. Ferrante, Mikhail B. Bogdanov, Rima Kaddurah-Daouk, M. Flint Beal

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 699 KB

english, 2001

16

Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study

Rima Kaddurah-Daouk, Rebecca A. Baillie, Hongjie Zhu, Zhao-Bang Zeng, Michelle M. Wiest, Uyen Thao Nguyen, Steven M. Watkins, Ronald M. Krauss

Journal:

Year:

2010

Language:

english

File:

PDF, 589 KB

english, 2010

17

Plasma Omega-3 Polyunsaturated Fatty Acids and Survival in Patients with Chronic Heart Failure and Major Depressive Disorder

Wei Jiang, Harry Oken, Mona Fiuzat, Linda K. Shaw, Carolyn Martsberger, Maragatha Kuchibhatla, Rima Kaddurah-Daouk, David C. Steffens, Rebecca Baillie, Michael Cuffe, Ranga Krishnan, Christopher O’Con

Journal:

Journal of Cardiovascular Translational Research

Year:

2012

Language:

english

File:

PDF, 163 KB

english, 2012

18

10.1038/6568

Beal, M. Flint, Klivenyi, Peter, Ferrante, Robert J., Matthews, Russell T., Bogdanov, Mikhail B., Klein, Autumn M., Andreassen, Ole A., Mueller, Gerald, Wermer, Marieke, Kaddurah-Daouk, Rima

Journal:

Nature Medicine

Year:

1999

Language:

english

File:

PDF, 181 KB

english, 1999

19

Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia

Yao, J K, Dougherty, G G, Reddy, R D, Keshavan, M S, Montrose, D M, Matson, W R, Rozen, S, Krishnan, R R, McEvoy, J, Kaddurah-Daouk, R

Journal:

Molecular Psychiatry

Year:

2009

Language:

english

File:

PDF, 560 KB

english, 2009

20

The Metabolomics Standards Initiative

Sansone, Susanna-Assunta, Fan, Teresa, Goodacre, Royston, Griffin, Julian L, Hardy, Nigel W, Kaddurah-Daouk, Rima, Kristal, Bruce S, Lindon, John, Mendes, Pedro, Morrison, Norman

Journal:

Nature Biotechnology

Year:

2007

Language:

english

File:

PDF, 281 KB

english, 2007

21

Metabolomic mapping of atypical antipsychotic effects in schizophrenia

Kaddurah-Daouk, R, McEvoy, J, Baillie, R A, Lee, D, Yao, J K, Doraiswamy, P M, Krishnan, K R R

Journal:

Molecular Psychiatry

Year:

2007

Language:

english

File:

PDF, 370 KB

english, 2007

22

Interest in metabolomics continues to grow within US National Institutes of Health (NIH)

Kaddurah-Daouk, Rima

Journal:

Year:

2012

Language:

english

File:

PDF, 139 KB

english, 2012

23

Creatine phosphate inhibits the replication of HIV in macrophages

L.J. Hansen, R. Kaddurah-Daouk

Journal:

Antiviral Research

Year:

1995

Language:

english

File:

PDF, 69 KB

english, 1995

24

Antiviral activity of phosphinic cyclocreatine (2-iminoimidazolidine-1-methyl phosphinic acid) against HCMV and HSV-1

B.G. Mulamba, L.J. Hansen, R. Kaddurah-DaouK

Journal:

Antiviral Research

Year:

1995

Language:

english

File:

PDF, 63 KB

english, 1995

25

Metabolomics tools for identifying biomarkers for neuropsychiatric diseases

Marlon P. Quinones, Rima Kaddurah-Daouk

Journal:

Neurobiology of Disease

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

26

Neuroprotective effects of creatine administration against NMDA and malonate toxicity

Cesar Malcon, Rima Kaddurah-Daouk, M.Flint Beal

Journal:

Year:

2000

Language:

english

File:

PDF, 156 KB

english, 2000

27

3-Hydroxykynurenine and clinical symptoms in first-episode neuroleptic-naive patients with schizophrenia

Condray, Ruth, Dougherty, George G., Keshavan, Matcheri S., Reddy, Ravinder D., Haas, Gretchen L., Montrose, Debra M., Matson, Wayne R., McEvoy, Joseph, Kaddurah-Daouk, Rima, Yao, Jeffrey K.

Journal:

The International Journal of Neuropsychopharmacology

Year:

2011

Language:

english

File:

PDF, 652 KB

english, 2011

28

Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity

Russell T. Matthews, Robert J. Ferrante, Peter Klivenyi, Lichuan Yang, Autumn M. Klein, Gerald Mueller, Rima Kaddurah-Daouk, M.Flint Beal

Journal:

Experimental Neurology

Year:

1999

Language:

english

File:

PDF, 1009 KB

english, 1999

29

Depletion of Energy Reserve via the Creatine Kinase Reaction During the Evolution of Heart Failure in Cardiomyopathic Hamsters

Rong Tian, Luigino Nascimben, Rima Kaddurah-Daouk, Joanne S. Ingwall

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1996

Language:

english

File:

PDF, 132 KB

english, 1996

30

Enhancement of cardiac function by cyclocreatine in models of cardiopulmonary bypass

Stuart L Houser, Ashraf F Elkerm, Zongjie Wei, Kathleen Doyle, Diane Houser, Xue Kun Liu, Edward Tyles, Rima Kaddurah-Daouk, Salwa A Elgebaly

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1995

Language:

english

File:

PDF, 677 KB

english, 1995

31

Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses

James W. Lillie, Donald F. Smee, John H. Huffman, Lori J. Hansen, Robert W. Sidwell, Rima Kaddurah-Daouk

Journal:

Antiviral Research

Year:

1994

Language:

english

File:

PDF, 939 KB

english, 1994

32

Metabolomic changes in autopsy-confirmed Alzheimer's disease

Rima Kaddurah-Daouk, Steve Rozen, Wayne Matson, Xianlin Han, Christine M. Hulette, James R. Burke, P. Murali Doraiswamy, Kathleen A. Welsh-Bohmer

Journal:

Alzheimer's & Dementia

Year:

2011

Language:

english

File:

PDF, 421 KB

english, 2011

33

Impaired plasmalogens in patients with schizophrenia

Rima Kaddurah-Daouk, Joseph McEvoy, Rebecca Baillie, Hongjie Zhu, Jeffrey K. Yao, Vishwajit L. Nimgaonkar, Peter F. Buckley, Matcheri S. Keshavan, Anastasia Georgiades, Henry A. Nasrallah

Journal:

Psychiatry Research

Year:

2012

Language:

english

File:

PDF, 341 KB

english, 2012

34

MULTIVARIATE COMPARISONS OF PLASMA MONOAMINE METABOLITES IN HEALTHY CONTROLS AND FIRST-EPISODE NEUROLEPTIC-NAÏVE PATIENTS WITH SCHIZOPHRENIA

Jeffrey Yao, George Dougherty, Ravinder Reddy, Matcheri Keshavan, Debra Montrose, Wayne Matson, Steve Rozen, Joseph McEvoy, Rima Kaddurah-Daouk

Journal:

Schizophrenia Research

Year:

2008

Language:

english

File:

PDF, 57 KB

english, 2008

35

ABNORMAL PURINE CATABOLISM IN FIRST-EPISODE NEUROLEPTIC-NAÏVE PATIENTS WITH SCHIZOPHRENIA

Jeffrey Yao, George Dougherty, Matcheri Keshavan, Debra Montrose, Wayne Matson, Steve Rozen, Joseph McEvoy, Rima Kaddurah-Daouk, Ravinder Reddy

Journal:

Schizophrenia Research

Year:

2008

Language:

english

File:

PDF, 76 KB

english, 2008

36

Alterations in metabolic pathways and networks in Alzheimer’s disease

Kaddurah-Daouk, R, Zhu, H, Sharma, S, Bogdanov, M, Rozen, S G, Matson, W, Oki, N O, Motsinger-Reif, A A, Churchill, E, Lei, Z, Appleby, D, Kling, M A, Trojanowski, J Q, Doraiswamy, P M, Arnold, S E

Journal:

Translational Psychiatry

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

37

Metabolomics Reveals Amino Acids Contribute to Variation in Response to Simvastatin Treatment

Trupp, Miles, Zhu, Hongjie, Wikoff, William R., Baillie, Rebecca A., Zeng, Zhao-Bang, Karp, Peter D., Fiehn, Oliver, Krauss, Ronald M., Kaddurah-Daouk, Rima, Oresic, Matej

Journal:

Year:

2012

Language:

english

File:

PDF, 505 KB

english, 2012

38

Biomarkers for amyotrophic lateral sclerosis

Bowser, Robert, Cudkowicz, Merit, Kaddurah-Daouk, Rima

Journal:

Expert Review of Molecular Diagnostics

Year:

2006

Language:

english

File:

PDF, 149 KB

english, 2006

39

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer’s disease from normal cognitive aging

Motsinger-Reif, Alison A, Zhu, Hongjie, Kling, Mitchel A, Matson, Wayne, Sharma, Swati, Fiehn, Oliver, Reif, David M, Appleby, Dina H, Doraiswamy, P Murali, Trojanowski, John Q, Kaddurah-Daouk, Rima,

Journal:

Acta Neuropathologica Communications

Year:

2013

Language:

english

File:

PDF, 218 KB

english, 2013

40

Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed Pharmacogenomics

Yerges-Armstrong, L M, Ellero-Simatos, S, Georgiades, A, Zhu, H, Lewis, J p, Horenstein, R B, Beitelshees, A L, Dane, A, Reijmers, T, Hankemeier, T, Fiehn, O, Shuldiner, A R, Kaddurah-Daouk, R

Journal:

Clinical Pharmacology & Therapeutics

Year:

2013

Language:

english

File:

PDF, 617 KB

english, 2013

41

Integration of Pharmacometabolomic and Pharmacogenomic Approaches Reveals Novel Insights Into Antiplatelet Therapy

Lewis, J P, Yerges-Armstrong, L M, Ellero-Simatos, S, Georgiades, A, Kaddurah-Daouk, R, Hankemeier, T

Journal:

Clinical Pharmacology & Therapeutics

Year:

2013

Language:

english

File:

PDF, 332 KB

english, 2013

42

Alterations in metabolic pathways and networks in mild cognitive impairment and early Alzheimer's disease

Kaddurah-Daouk, Rima, Doraiswamy, P. Murali, Zhu, Hongjie, Kling, Mitchel, Arnold, Steven, Trojanowski, John, Saykin, Andrew, Shen, Li, Kim, Sungeun, Nho, Kwangsik, Matson, Wayne, Han, Xianlin, Sharma

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 200 KB

english, 2013

43

Metabolomics: A Global Biochemical Approach to the Study of Central Nervous System Diseases

Kaddurah-Daouk, Rima, Krishnan, K Ranga Rama

Journal:

Neuropsychopharmacology

Year:

2009

Language:

english

File:

PDF, 488 KB

english, 2009

44

Establishing Reporting Standards for Metabolomic and Metabonomic Studies: A Call for Participation

Fiehn, Oliver, Kristal, Bruce, Ommen, Ben Van, Sumner, Lloyd W., Sansone, Susanna-Assunta, Taylor, Chris, Hardy, Nigel, Kaddurah-Daouk, Rima

Journal:

Omics A Journal of Integrative Biology

Year:

2006

Language:

english

File:

PDF, 63 KB

english, 2006

45

Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept

Kaddurah-Daouk, R, Boyle, S H, Matson, W, Sharma, S, Matson, S, Zhu, H, Bogdanov, M B, Churchill, E, Krishnan, R R, Rush, A J, Pickering, E, Delnomdedieu, M

Journal:

Translational Psychiatry

Year:

2011

Language:

english

File:

PDF, 326 KB

english, 2011

46

Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo

Kaddurah-Daouk, R, Bogdanov, M B, Wikoff, W R, Zhu, H, Boyle, S H, Churchill, E, Wang, Z, Rush, A J, Krishnan, R R, Pickering, E, Delnomdedieu, M, Fiehn, O

Journal:

Translational Psychiatry

Year:

2013

Language:

english

File:

PDF, 668 KB

english, 2013

47

Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review

Emwas, Abdul-Hamid, Luchinat, Claudio, Turano, Paola, Tenori, Leonardo, Roy, Raja, Salek, Reza M., Ryan, Danielle, Merzaban, Jasmeen S., Kaddurah-Daouk, Rima, Zeri, Ana Carolina, Nagana Gowda, G. A.,

Journal:

Year:

2015

Language:

english

File:

PDF, 452 KB

english, 2015

48

Activation and repression of mammalian gene expression by the c-myc protein.

Kaddurah-Daouk, R, Greene, J M, Baldwin, A S, Kingston, R E

Journal:

Genes & Development

Year:

1987

Language:

english

File:

PDF, 4.52 MB

english, 1987

49

Metabolomic Differences in Heart Failure Patients With and Without Major Depression

Steffens, D. C., Wei Jiang,, Krishnan, K. R. R., Karoly, E. D., Mitchell, M. W., O'Connor, C. M., Kaddurah-Daouk, R.

Journal:

Journal of Geriatric Psychiatry and Neurology

Year:

2010

Language:

english

File:

PDF, 240 KB

english, 2010

50

Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics

Rasmussen, Henrik Berg, Bjerre, Ditte, Linnet, Kristian, Jürgens, Gesche, Dalhoff, Kim, Stefansson, Hreinn, Hankemeier, Thomas, Kaddurah-Daouk, Rima, Taboureau, Olivier, Brunak, Søren, Houmann, Tine,

Journal:

Pharmacogenomics

Year:

2015

Language:

english

File:

PDF, 1.46 MB

english, 2015